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. 2015 Jul 17;6(28):25770–25783. doi: 10.18632/oncotarget.4514

Figure 5. Inhibitors of ATM or ATR enhance the sensitivity of MCF-7 cells to BO-1055.

Figure 5

A. Immunoblot analysis showing DDR in MCF-7 cells with or without exposure to 5 μM of BO-1055 alone, or co-treatment with 10 μM of NU6027 (BO+NU6027) or 10 μM of KU55933 (BO+KU55933) for 6-h. B. Immunoblot analysis showing cell death, assessed by detecting the expression of pro-caspase-7, pro-caspase-8, pro-caspase-9, or PARP following the exposure of MCF-7 cells to 5 μM of BO-1055 alone, or with co-treatment with 10 μM of NU6027 or 10 μM of KU55933 for 72-h. C. In vitro clonogenic survival of ATM or ATR activity inhibition in MCF-7 cells, by pre-treatment with 10 μM of NU6027 or 10 μM of KU55933 for 30 min, followed by exposure to 5 μM of BO-1055 for 6-h.