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. 2015 Jul 23;6(28):25784–25800. doi: 10.18632/oncotarget.4703

Figure 10. Inhibition of 5-LO mRNA expression by class I HDAC inhibitors or the CDK9 inhibitor Flavopiridol in MV4-11 cells.

Figure 10

MV4-11 cells were differentiated with (50 nM) and TGFβ (1 ng/ml) and cultured in the presence of HDAC inhibitors or the CDK9 inhibitor Flavopiridol as indicated. After 24 hours, cells were harvested and 5-LO mRNA expression was determined by real-time PCR in three independent experiments. One sample t-test was performed to determine the significance of inhibitor treatment, indicated by asterisks (*P < 0.05, **P < 0.01, ***P < 0.001).