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. 2015 Jul 16;6(28):25828–25842. doi: 10.18632/oncotarget.4558

Figure 2. α-Mangostin and rTRAIL significantly induced growth suppression by causing up-regulation of DR5.

Figure 2

TRAIL-sensitive and -resistant DLD-1 cells were treated with α-mangostin (2, 5, 7 μM) and/or rTRAIL (5 ng/ml) for 48 h. The cell viability was estimated at 48 h after the treatment. Data were obtained from 3 independent experiments. The cell viability of the control (0; DMSO alone) is indicated as 100%. Western blot analysis was performed to determine the level of DR5 and activation of caspase-8. β-actin was used as an internal control.