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. 2015 Jul 16;6(28):25828–25842. doi: 10.18632/oncotarget.4558

Figure 3. α-Mangostin effectively induced DR5 oligomerization at the cell surface membrane.

Figure 3

TRAIL-sensitive and -resistant DLD-1 cells were treated with α-mangostin (7 μM) and/or rTRAIL (5 ng/ml) for 48 h. The results of immunofluorescence staining for anti-DR5 binding on the cell surface and in the cytosol of untreated (Control; DMSO) or α-mangostin and /or rTRAIL treated cells are shown. Nuclei were counterstained in blue with Hoechst33342. Anti-DR5 bound to the cell surface is indicated by white arrows.