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. 2015 Jul 17;6(28):25975–25987. doi: 10.18632/oncotarget.4543

Figure 3. 5-HT1DR regulated Axin1/β-catenin/LEF1/TCF4/MMP-7 signaling pathway.

Figure 3

A & B. Western blots showing expressions of Axin1, β-catenin, LEF, TCF4, MMP-7, cyclin D1, c-Myc, MMP-2 and MMP-9 in response to transfection with lentivirus-control (Vector), Axin1 lentivirus (Axin1over), 5-HT1D agonist or co-transfection with sumatriptan and Axin1 lentivirus (Axin1over) for 48 h as described in Materials. Quantification of the relative Axin1, β-catenin, LEF, TCF4, MMP-7 expression. Values are means ± SEM. (significant differences are indicated by *P < 0.05, **P < 0.01). C. Proposed working model of the noted 5-HT1DR lead of Axin1/β-catenin/LEF1/TCF4/MMP-7 signaling pathway mediated invasion and migration in colorectal cancer cells.