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. 2015 Jul 17;6(28):25988–26001. doi: 10.18632/oncotarget.4620

Table 1. List of significant altered protein identified by MALDI-Q-TOF in bortezomib-treated Daudi cells.

Protein name (Calculates kDa, PI) SWISS-PROT number Mascot score Change folds Cellular location Molecular function
14-3-3 β/α (28.5, 4.73) P31946 56 +95.32 Cytoplasm, melanosome Ras protein signal transduction, apoptosis
PRDX6 (23.8, 5.65) P30041 89 +74.21 Cytoplasm, lysosome Antioxidant activity, redox regulation
hnRNP K (51.0, 5.99; 50.0, 6.30) P61978 39; 90 +62.77; +19.92 Cytoplasm, nucleus hnRNP, mRNA processing
hnRNP H (57.0, 6.08) P31943 315 +40.00 Nucleus, nucleoplasm hnRNP, mRNA processing
RGDI-2 (24.2, 6.88) P52566 73 +20.17 Cytoplasm Regulates the GDP/GTP exchange
LamR (44.6, 4.70) P08865 67 +14.74 Cytoplasm Translational elongation, cell adhesion
eIF4A-I (49.7, 5.59) P60842 186 +10.89 Cytoplasm Protein biosynthesis
β-actin (47.1, 5.98; 43.9, 5.96; 46.7, 5.82) P60709 89; 101; 249 +10.88; +5.98; +3.02 Cytoplasm, cytoskeleton Structural protein, cell motility
hnRNP C1/C2 (41.7, 5.28) P07910 124 +8.06 Nucleus hnRNP, mRNA processing
α-tubulin 3 (57.2, 5.40; 57.6, 5.33) Q71U36 228; 233 +6.33; +3.07 Cytosteleton Microtubules
Hsp90α (96.1, 4.91) P07900 112 +5.24 Cytoplasm, melanosome Stress response, chaperone
Grp78 (80.6, 4.96) P11021 237 +3.71 Endoplasmic reticulum Stress response, anti-apoptosis
Hsp7C (74.5, 5.39) P11142 102 +2.86 Cytoplasm, melanosome Stress response, chaperone
14-3-3 ε (28.5, 4.67) P62258 83 +2.29 Cytoplasm, melanosome Adapter protein, intracellular signaling
TDP-43 (49.1, 6.05) Q13148 160 −2.33 Nucleus Transcription regulation, mRNA processing
RGDI-2 (26.7, 5.10) P52566 128 −2.50 Cytoplasm Regulates the GDP/GTP exchange
Hsp60 (63.8, 5.21; 64.1, 5.36) P10809 90; 299 −2.95; −3.45 Mitochondrion matrix Chaperone, regulation of apoptosis
hnRNP F (52.4, 5.41) P52597 99 −3.21 Nucleus, nucleoplasm hnRNP, mRNA processing
RPLP0 (39.9, 5.67) P05388 92 −3.57 Ribonucleoprotein Translational elongation
hnRNP K (64.5, 5.12; 64.2, 5.51) P61978 65; 52 −3.70; −2.38 Cytoplasm, nucleus hnRNP, mRNA processing
PA28g (33.6, 5.83) P61289 260 −5.88 Proteasome Immunoproteasome assembly