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. 2015 Jul 20;6(28):26029–26040. doi: 10.18632/oncotarget.4347

Figure 6. SGK1 inhibition reduces ARW741L activity and attenuates LNCaP-ARW741L proliferation.

Figure 6

A. LNCaP-ARW741L cells depleted of ART877A were treated with 10 μM SGK inhibitor GSK650395 for 24 hours prior to quantitative analysis of SGK1 expression. B. As above, but cells were treated with GSK650395 for 96 hours in the presence and absence of 10 nM bicalutamide prior to proliferation analysis. C. In silico SGK1, TIPARP and RASD1 expression profiling in 150 primary prostate cancer specimens (28); ARW741C-expressing patient sample is indicated in green.