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. 2015 Jul 20;6(28):26041–26051. doi: 10.18632/oncotarget.4667

Figure 1. ZIP4 knockdown relieved bone resorption.

Figure 1

Representative 3-D Micro-CT images of trabecular bone microarchitecture above the growth plate of the distal end of the femur in SHAM A. AsPC-shV B. and AsPC-shZIP4 groups C. A volume of interest with 1.2 mm height was selected for the analysis of trabecular bone micro-architecture. All of the trabecular TMD of mice bearing pancreatic xenograft tumors of AsPC-1 cells presented an overall decrease. The femurs in the AsPC-shZIP4 group exhibited significant increase in the TMD and bone volume fraction as compared with that in the AsPC-shV group D, E. Qualitative analysis of trabecular bone revealed that silencing of ZIP4 in AsPC-1 cells (AsPC-shZIP4 group) could restore the decreased trabecular thickness, but exhibited no significant effect on the trabecular number F, G. *P < 0.05.