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. 2015 Jul 17;6(28):26065–26078. doi: 10.18632/oncotarget.4569

Figure 4. AR transcriptionally up-regulates MMP1 and MMP13 by binding to their promoters.

Figure 4

a. Predicted localization of AREs in MMP1 (top lane) and MMP13 promoter region (bottom lane). b. J82-oeAR/vector cells were transfected with MMP1/MMP13-pGL3 luciferase reporter plasmid and pCMVtk vector was used as an internal control for transfection efficiency. After 36 hrs transfection, luciferase activities in triplicate samples were measured. (*P < 0.05) c. ChIP analysis of AR binding to the MMP1/MMP13 promoters.