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. 2015 Jul 20;6(28):26079–26089. doi: 10.18632/oncotarget.4581

Figure 3. Knock-down of eIF5A2 increased chemosensitivity.

Figure 3

A. Knock-down of eIF5A2 by shRNAs (sh1 and sh2) compared with vector control was confirmed in KYSE180 cells by western blotting analysis. Tubulin was set as loading control. B, C. The eIF5A2 knock-down cells (180-sh1 and 180-sh2) were significantly more sensitive than the vector cells at individual 5-FU (B), docetaxel and taxol (C) doses. *, P < 0.05; **, P < 0.01. D. Knock-down of eIF5A2 was confirmed in EC109 cells by western blotting analysis. Tubulin was set as loading control. E. F. The eIF5A2 knock-down EC109 cells were significantly more sensitive than the vector cells at individual 5-FU (E), docetaxel and taxol (F) doses. *, P < 0.05; **, P < 0.01.