Figure 1. Binding mode of saracatinib, dasatinib, and bosutinib in the EGFR kinase domain (PDB 2ITT) as predicted by docking calculations.

The protein is depicted as cyan and white ribbons and surface, respectively. Key hinge region residue M793 is depicted as cyan sticks. Saracatinib, dasatinib, and bosutinib are represented as pink, orange, and yellow sticks, respectively. H-bond interactions are represented as dashed yellow lines.