Figure 5. Effects of the combination dasatinib plus selumetinib on Ras-dependent human NSCLC models.
A. Percent of survival of H1299 and Calu3-ER cells treated for 72 hours with different concentrations of dasatinib, alone or in combination with selumetinib, as measured by MTT assay. **, 2-sided P < 0.01 versus selumetinib alone. B. Western blot analysis of H1299 and Calu3-ER cells treated for 3 hours with dasatinib, alone or in combination with selumetinib. The maximum doses used in MTT assays have been chosen for Western blot analysis.