Table 1. Effect of Src inhibitors on EGFR TK catalytic activity.

	EGFR d746-750	EGFR d747-749 A750P	EGFR d747-752 P753S	EGFR d752-759	EGFR G719C	EGFR G719S	EGFR L858R	EGFR L861Q	EGFR T790M	EGFR T790M/L858R	EGFR wt
Compound	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)	IC50 (nM)
Saracatinib	13.1	13.3	10.0	36.2	9.77	13.5	9.40	12.3	769	802	11.0
Dasatinib	54.7	64.0	61.2	138	24.8	21.7	28.1	25.5	3100	2790	25.4
Bosutinib	2.53	5.80	3.47	23.7	2.59	2.25	2.29	3.95	145	214	3.17
Erlotinib	1.56	2.40	1.57	2.33	2.30	2.22	1.62	1.24	200	999	1.01

Compound concentrations in the assay from 0.3 nM to 10 μM, semi-log steps; singlicate measurement Ranking of IC50 values: