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. 2015 Jul 20;6(28):26177–26191. doi: 10.18632/oncotarget.4614

Figure 1. Schematic representation of the EGFR-based gene delivery system.

Figure 1

a. Electrostatic interactions of PAMAM and DNA to form dendriplexes. b. Self-assembled h-R3-dendriplexes via electrostatic adsorption of dendriplexes to negatively charged h-R3. c. h-R3-dendriplexes for targeted tumor gene therapy. 1, specific binding to the EGFR overexpressing receptors on the tumor cells; 2, receptor-mediated endocytosis; 3, captured by the lysosomes; 4, lysosomal escape and accumulation in the nucleus.