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. 2015 Jul 20;6(28):26192–26215. doi: 10.18632/oncotarget.4613

Figure 4. Correlation between gene expression and the survival of GBM patients.

Figure 4

A. The correlation between gene expression and survival was calculated using the set of 200 GBM samples from the TCGA database described in Verhaak et al., 2010 [24]. This material contained 54 classical, 58 mesenchymal, 57 proneural and 33 neural GBM tissue samples. Using hierarchical clustering, the patients were sorted according to the expression of the nine genes in gene cluster I (from Figure 3A). B. The survival times of GBM patients with the highest and lowest expression of the nine genes were compared. The subclassification of these patient groups is described in the text on the left (high = blue and low = red). This analysis showed that the concurrent high expression of the nine genes had a negative effect on patient survival (median survival reduced from 383 to 290 days). The calculated p value was p = 0.00196 (Gehan-Breslow-Wilcoxon test). C. The survival times of mesenchymal subtype of GBM patients with the highest and lowest expression of the nine genes were compared (median survival reduced from 468 to 199 days). The calculated p value was p = 0.0039 (Gehan-Breslow-Wilcoxon test).