Figure 6. Protein-protein interactions among the proteins encoded by the 20 selected genes and the principal regulators of stemness, growth and tumorigenicity in GSCs.

By querying the COGNESCENTE database we obtained information on protein-protein interactions documented in the literature. Fourteen of the proteins encoded by the selected 20 genes were interconnected and built a network. Several of these (PBK, CENPA, CDC6, EZH2, MPP6 and MCC) were highly interconnected and could be called network “hubs”. For clarity of the image the list of queried genes was limited to the 20 selected genes, and BMI1 and HIF1A. For a detailed image with all interactions see Supplementary Figure S8.