| cluster 1 |
MTOR-CENPA |
no |
RUVBL1, RUVBL2, DDB1 |
| MTOR-EZH2 |
no |
SIRT1, C7ORF25, PML, AKT1 |
| DLL3-EZH2 |
no |
NRF1 |
| DLL3-KIF18A |
no |
NRF1 |
| STAT3-EZH2 |
no |
RPS6K5, ESR1, HDAC1, HDAC2, HDAC3, PML, RELA, KDM1A, MYOD1, SRC, MAP3K7, DNMT1, ASXL1 |
| STAT3-CENPA |
no |
SRRT |
| STAT3-DLG7/DLGAP |
no |
SUMO2 |
| STAT3-DEPDC1 |
no |
ELAVL1 |
| CENPA-EZH2 |
no |
HIST1H1A |
| DLG7-EZH2 |
no |
CDK1 |
| UBC-(MTOR, STAT3, EZH2, DEPDC1, KIF15, KIF18A and DLG7) |
yes |
|
| cluster 2 |
EGFR-PBK |
no |
H2AFX, CALM1, HSP90AB1, HSPA5, HSPA8, HSPA1A, PRDX1, TUBB, HBA1, JUP and CDC37 |
| EGFR-RHBDD1 |
no |
FBXO25, UBC |
| cluster 3 |
SOX2-CDC6 |
no |
FZR1, BMI1 and CDK1 |
| SOX2-HMMR |
no |
TUBB2A |
| SOX2-MPP6 |
no |
SKIV2L2 |
| NF1-MPP6 |
no |
SMARCA4 |
| NRF1-(HMMR, NF1, MPP6) |
yes |
|
| UBC-(NF1, FNDC3B, HMMR, MPP6, CDC6) |
yes |
|
| INTERACTIONS ACROSS CLUSTERS |
| clusters 1, 2 and 3 |
EZH2-CDC6 |
no |
CDK2, CDK6, RBL2, UBB |
| MCC-DLG7 |
no |
APP |
| MCC-HMMR |
no |
CSNK1E |
| HMMR-CENPA |
no |
ACTB |
| PBK-CENPA |
no |
HNRNPU, H2AFX, HIST4H4, HIST1H1C, HSPA8 |
| PBK-KIF15 |
no |
KIAA1377, VIM |
| PBK-CDC6 |
no |
CCNB1, RPS27A, E2F4 (DNA-protein binding), MYC |
| PBK-HMMR |
no |
CALM1 |
| PBK-DLG7 |
no |
TRIM37 |
| PBK-EZH2 |
no |
RBBP4, CDK1 |
| OTHER INTERACTIONS |
|
HIF1A-EZH2 |
no |
HDAC1, HDAC2, HDAC3, RELA, ESR1, CTNNB1, SRC |
|
EZH2-STAT3 |
no |
HDAC1, HDAC2, HDAC3, RELA, ESR1, |
|
HIF1A-CDC6 |
no |
MCM3, MCM7, CDKN2A |
|
HIF1A-MPP6 |
no |
SMARCA4, NDN |
|
HIF1A-HMMR |
no |
BRCA1. MAPK1 |
|
HIF1A-MCC |
no |
VCP, VHL |
|
HIF1A-CENPA |
no |
RUVBL2, PARP1, HSPA8 |
|
HIF1A-PBK |
no |
CSNK2A1 and HSPA8 |
|
HIF1A-DLG7 |
no |
SUMO2 |
|
BMI1-CENPA |
yes |
XRCC5, PARP1, CBX8, PRKDC, RING1, RNF2, H2AFX |
|
BMI1-CDC6 |
yes |
ATM |
|
BMI1-PBK |
no |
H2AFX, KIAA137, TP53, CSNK2B |
|
BMI1-EZH2 |
no |
E2F6, MAPKAPK3 and USP7 |
|
BMI1-PBK |
no |
H2AFX, KIAA137, TP53, CSNK2B |
|
BMI1-KIF15 |
no |
KIAA137 |
|
BMI1-DLG7 |
no |
BTRC |
|
BMI1-MPP6 |
no |
UBC |
|
SALL2- CENPA |
no |
DDB1 |
|
SALL2- PBK |
no |
RBBP7 |
|
SALL2- SOX2 |
no |
RBBP7 |
|
POU3F2-OLIG2 |
no |
SOX10 |
|
POU3F2-OLIG2-HIF1A |
no |
EP300 |
|
CDK1-(PBK, CDC6, DLG7, EZH2) |
yes |
|
