Table 4. Enriched GO functional terms of exclusively disrupted genes in CRC cases.
| Category 1 | Term | Count 2 | % 3 | P Value | Bonferroni |
|---|---|---|---|---|---|
| Rare CNVs exclusive to colorectal cancer | |||||
| GOTERM_CC | GO:0000786~nucleosome | 15 | 2.60 | 7.95E-09 | 2.80E-06 |
| GOTERM_CC | GO:0032993~protein-DNA complex | 17 | 2.94 | 1.05E-08 | 3.68E-06 |
| GOTERM_BP | GO:0031497~chromatin assembly | 16 | 2.77 | 6.79E-08 | 1.30E-04 |
| GOTERM_BP | GO:0006333~chromatin assembly or disassembly | 19 | 3.29 | 7.81E-08 | 1.50E-04 |
| GOTERM_BP | GO:0065004~protein-DNA complex assembly | 16 | 2.77 | 1.26E-07 | 2.42E-04 |
| GOTERM_BP | GO:0006334~nucleosome assembly | 15 | 2.60 | 2.89E-07 | 5.53E-04 |
| GOTERM_BP | GO:0006323~DNA packaging | 17 | 2.94 | 6.80E-07 | 1.30E-03 |
| GOTERM_BP | GO:0034728~nucleosome organization | 15 | 2.60 | 1.04E-06 | 2.00E-03 |
| GOTERM_CC | GO:0000785~chromatin | 22 | 3.81 | 1.60E-06 | 5.64E-04 |
| GOTERM_CC | GO:0005694~chromosome | 35 | 6.06 | 4.41E-06 | 1.55E-03 |
| GOTERM_BP | GO:0007608~sensory perception of smell | 32 | 5.54 | 1.36E-05 | 2.57E-02 |
| GOTERM_BP | GO:0034622~cellular macromolecular complex assembly | 26 | 4.50 | 2.17E-05 | 4.07E-02 |
| GOTERM_MF | GO:0004984~olfactory receptor activity | 31 | 5.36 | 3.59E-05 | 2.15E-02 |
| GOTERM_CC | GO:0044427~chromosomal part | 29 | 5.02 | 4.35E-05 | 1.52E-02 |
| GOTERM_CC | GO:0045095~keratin filament | 12 | 2.08 | 1.05E-04 | 3.64E-02 |
| Rare CNVs exclusive to colon cancer | |||||
| GOTERM_CC | GO:0032993~protein-DNA complex | 16 | 4.78 | 6.16E-11 | 1.69E-08 |
| GOTERM_CC | GO:0000786~nucleosome | 14 | 4.18 | 1.32E-10 | 3.62E-08 |
| GOTERM_BP | GO:0006333~chromatin assembly or disassembly | 18 | 5.37 | 2.66E-10 | 4.02E-07 |
| GOTERM_BP | GO:0031497~chromatin assembly | 15 | 4.48 | 8.81E-10 | 1.33E-06 |
| GOTERM_CC | GO:0000785~chromatin | 21 | 6.27 | 1.25E-09 | 3.45E-07 |
| GOTERM_BP | GO:0065004~protein-DNA complex assembly | 15 | 4.48 | 1.63E-09 | 2.46E-06 |
| GOTERM_BP | GO:0006323~DNA packaging | 16 | 4.78 | 5.65E-09 | 8.54E-06 |
| GOTERM_BP | GO:0006334~nucleosome assembly | 14 | 4.18 | 5.85E-09 | 8.83E-06 |
| GOTERM_BP | GO:0034728~nucleosome organization | 14 | 4.18 | 2.08E-08 | 3.15E-05 |
| GOTERM_CC | GO:0044427~chromosomal part | 25 | 7.46 | 3.15E-07 | 8.67E-05 |
| GOTERM_CC | GO:0005694~chromosome | 27 | 8.06 | 6.24E-07 | 1.72E-04 |
| GOTERM_BP | GO:0034622~cellular macromolecular complex assembly | 22 | 6.57 | 7.35E-07 | 1.11E-03 |
| GOTERM_CC | GO:0045095~keratin filament | 12 | 3.58 | 7.91E-07 | 2.18E-04 |
| GOTERM_BP | GO:0034621~cellular macromolecular complex subunit organization | 22 | 6.57 | 4.64E-06 | 6.98E-03 |
| GOTERM_BP | GO:0065003~macromolecular complex assembly | 30 | 8.96 | 2.56E-05 | 3.79E-02 |
| GOTERM_CC | GO:0043228~non-membrane-bounded organelle | 74 | 22.09 | 1.58E-04 | 4.24E-02 |
| GOTERM_CC | GO:0043232~intracellular non-membrane-bounded organelle | 74 | 22.09 | 1.58E-04 | 4.24E-02 |
| Rare CNVs exclusive to rectal cancer | |||||
| none | |||||
1
BP, biological process; CC, cellular component; MF, molecular function.
2
Count, number of DAVID gene IDs identified in specific GO terms. Note that the number may be different with the number of Ensembl gene IDs as DAVID incorporates some functionally similar Ensembl gene IDs into one DAVID gene ID according to DAVID Knowledgebase.
3
%, (Count of involved genes / Total number of genes within a particular term) *100.