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. 2015 Sep 22;6(29):26633–26650. doi: 10.18632/oncotarget.5782

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Copyright: © 2015 Adams et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. In vivo transplantation of 5,000 UM-HMC-3B (passage 103) FACS-sorted cells (CD44^highCD24^high, CD44^highCD24^low, CD44^lowCD24^high, or CD44^lowCD24^low) with 900,000 endothelial (HDMEC) cells seeded on biodegradable scaffolds and transplanted into the subcutaneous space of SCID mice. B. Kaplan-Meyer analysis of time to palpability of tumors generated with cell sorted for CD44/CD24. Tumors were considered palpable once they reached 200 mm³. C. H&E staining of tumors generated by the transplantation of UM-HMC-3B cells sorted for CD44/CD24. Images were taken at 40X and 100X. D. Regression analysis of growth after palpability (200 mm³) of tumors generated with cells FACS-sorted for CD44 and CD24. E. Graph depicting the percentage of ALDH^high cells in tumors generated with cells FACS-sorted for CD44/CD24. F. Table depicting the number of tumors formed in each CD44/CD24 sorted sup-population in both the UM-HMC-3B cell line and the UM-HMC-3B low passage cell line xenograft model.