Table 1. Relationship between SPHK1 expression and clinicopathologic characteristics.
| Characteristics | Total | SPHK1 expression | p value | ||
|---|---|---|---|---|---|
| High | Low | ||||
| Age (years) | ≥49 | 141 | 87 (61.7) | 54 (38.3) | 0.475 |
| <49 | 146 | 96 (65.8) | 50 (34.2) | ||
| Tumor size (cm) | ≥4.0 | 132 | 81 (80.2) | 20 (19.8) | <0.001* |
| <4.0 | 155 | 102 (54.8) | 84 (45.2) | ||
| Depth of invasion (cm) | ≥1.0 | 159 | 124 (78.0) | 35 (22.0) | <0.001* |
| <1.0 | 128 | 59 (46.1) | 69 (53.9) | ||
| Lymph node metastasis | Present | 77 | 57 (74.0) | 20 (26.0) | 0.029* |
| Absent | 210 | 126 (60.0) | 84 (40.0) | ||
| FIGO stage | IA | 15 | 9 (60.0) | 6 (22.4) | 0.029* |
| IB | 214 | 129 (60.3) | 85 (39.7) | ||
| II | 58 | 45 (77.6) | 13 (22.4) | ||
| Lymphovascular invasion | Present | 130 | 91 (70.0) | 39 (30.0) | 0.045* |
| Absent | 157 | 92 (58.6) | 65 (41.4) | ||
| Parametrial invasion | Present | 33 | 23 (69.7) | 10 (30.3) | 0.451 |
| Absent | 254 | 160 (63.0) | 94 (37.0) | ||
| Resection margin involvement | Present | 14 | 10 (71.4) | 4 (28.6) | 0.777 |
| Absent | 273 | 173 (63.4) | 100 (36.6) | ||
| Preoperative SCC (ng/mL) | ≥1.5 | 137 | 98 (71.5) | 39 (28.5) | 0.009* |
| <1.5 | 150 | 85 (56.7) | 65 (43.3) | ||
*
Statistically significant (p < 0.05).