Figure 6. Target-specific intraperitoneal photosthermal therapy of human ovarian cancer.

One million TOV21G-luc cells were intraperitoneally injected into NOD/SCID mice. After 7 days, 2 mL of pSGNs conjugated with anti-human CD47 antibodies (OD₈₀₀ = 0.625) or isotype pSGNs (OD₈₀₀ = 1.5) were intraperitoneally injected into tumor-bearing mice. Mice that were intraperitoneally injected with 2 mL of 10% trehalose were used as controls. One day after pSGNs injection, the mice were irradiated using an 808-nm NIR laser (3.2 W/cm²) in five areas of the abdomen for 5 min. Tumor growth curves were represented by the chemoluminescent intensity and determined using an IVIS spectrum system. Compared with other groups, the group treated with anti-human CD47 conjugated pSGNs and NIR laser irradiation had the strongest therapeutic effect on the human ovarian cancer cell xenograft model. The error bar represents standard error. (P < 0.05#, <0.01*)