Skip to main content
. 2015 Aug 22;6(29):26909–26921. doi: 10.18632/oncotarget.4817

Figure 4. Stable knockdown of SREBP2 sensitizes breast cancer MDA-MB-231 and MCF7 cells to the pro-apoptotic and anti-proliferative effects of fluvastatin.

Figure 4

A-F. Protein lysates harvested from asynchronously growing MDA-MB-231 and MCF7 cells were immunoblotted for SREBP2 protein expression relative to cells transduced with the shControls (A and D respectively). Fluvastatin IC50 values in the MDA-MB-231 and MCF7 cell lines expressing the SREBP2 shRNAs were significantly lower when compared to the control cell lines (B and E respectively). Exposure of representative MDA-MB-231 and MCF7 cell lines to sub-lethal doses of fluvastatin caused a significant increase in apoptosis (C and F respectively). *p < 0.05 (t-test, unpaired, two-tailed, comparison made within each cell line). Immunoblots represent a minimum of two independent experiments.