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. 2015 Aug 11;6(29):27130–27145. doi: 10.18632/oncotarget.4825

Figure 1. The positive correlation between RFPL3, CBP and hTERT expression in NSCLC cells and tissues.

Figure 1

A. NSCLC patients` fresh tumor specimens and matched normal lung tissues (distance from tumor over 3 cm) were gathered and the expressions of RFPL3, CBP and hTERT proteins were tested by Western blot. Densitometric analysis was used to quantitatively analyze the level of protein bands. B. RFPL3 and CBP protein expressions were respectively correlated positively with hTERT expression in tumor tissues through quantitative analysis of the Western blot data. (Pearson's Correlation test, r = 0.55; P < 0.001). C. The average expression level of hTERT in the tumor tissues with both high expression of RFPL3 and CBP, or with both low expression of RFPL3 and CBP, or with one high and the other low based on the quantitative analysis of the Western blot data. CBP-/RFPL3-: simultaneous low expression of RFPL3 and CBP, CBP+/RFPL3- or CBP-/RFPL3+: one high and the other low among RFPL3 and CBP, CBP+/RFPL3+: simultaneous high expression of RFPL3 and CBP. D. Expression of RFPL3, CBP, and hTERT in the NSCLC cell lines (H1299, H460, H322, A549) and in normal lung cell lines (HLF) by Western blot.