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. 2015 Sep 16;6(29):27146–27159. doi: 10.18632/oncotarget.4354

Figure 7. Proposed mechanism of IWR-1 related to EMT and survivin in colorectal cancer cells.

Figure 7

A. EMT process in the colorectal cancer (CRC) cells. B. Action of IWR-1. Activation of the Wnt/β-catenin and PI3K/Akt pathways promotes EMT by increasing survivin expression. IWR-1 is known to block Wnt/β-catenin signaling by promoting β-catenin destruction in the β-catenin destruction complex. In this study, we have shown that IWR-1 can also inhibit EMT progression of CRC cells by directly suppressing survivin expression.