Figure 7. HBXIP enhances the growth of breast cancer cells through miR-183/96/182 targeting SCO2 and PDHA1 in vivo.

A. The growth curves of tumors derived from MCF-7 and MCF-HBXIP cells were shown. B. The protein levels of HBXIP, PDHA1, SCO2 and HIF1α were detected by Western blot analysis in the xenograft tumor tissues from above mice. C. The expression of PDHA1, SCO2, HIF1α and Ki67 was tested by IHC analysis in the tumor tissues from above mice. D. A model of HBXIP modulating SCO2 and PDHA1 involved in the glucose metabolism reprogramming is summarized, in which a feedback loop of HIF1α/miR-183/pVHL/HIF1α modulated by HBXIP contributes to the glucose metabolism reprogramming in breast cancer cells. Statistically significant differences are indicated: **P < 0.01, Student's t-test.