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. 2015 Aug 6;6(29):27214–27226. doi: 10.18632/oncotarget.4877

Figure 5. Pterostilbene induces PTEN expression and apoptosis, inhibits tumor cell proliferation and downregulates circulating tumor-derived oncomiRs in vivo.

Figure 5

A. Representative H&E and IHC images of PTEN, Ki-67 (proliferation); cleaved caspase-3 and M30 (apoptosis) staining in EV and miR-17/106a MIMIC xenografts upon pterostilbene treatment (magnification x100). B. Percent quantitation of Ki-67 and cleaved Caspase-3 staining is shown (n = 3 per group). C. Pterostilbene downregulated oncomiRs in serum of xenograft mice. Quantitative RT-PCR analysis of circulating levels of miRs-17-5p and -106a-5p in sera (n = 3 per group) from EV MIMIC and miR-17/106a MIMIC xenograft mice. Data represents the mean ± SEM of three independent experiments. Comparisons between EV and miR-overexpressing tumors (#) and vehicle and Pter-treated samples (*) is depicted. #p < 0.05; *p < 0.05; **p < 0.01. D. Proposed model of miR-regulated anticancer activity of dietary stilbenes. Pterostilbene and resveratrol inhibit expression of PTEN targeting miR-17 family oncomiRs, which leads to rescue of tumor suppressor PTEN expression resulting in inhibition of tumor growth. Pter, pterostilbene.