Figure 1. Poly-ICLC restricts tumor growth in murine models of liver tumors.
A&B. C57BL/6 mice transplanted with Hepa 1-6 cells were treated with PBS or poly-ICLC (pIC) on the indicated days (arrows). n = 5 each group. A. Slowed tumor growth indicated as reduced tumor areas (mm2) in mice treated with pIC versus PBS on d10: 25.0 ± 6.7 vs. 46.0 ± 7.5; p < 0.0001 and on d14: 38.8 ± 11.6 vs.65.2 ± 8.3; p < 0.0001. B. Left, Reduced final tumor weights (g) on d16 (†) in pIC- versus PBS-treated mice: 0.035 ± 0.022 vs.0.077 ± 0.017; p = 0.03. Right, representative images of tumors harvested from treated mice. Diameter of 6-well plate = 38 mm. C&D. C57BL/6mice were induced to develop spontaneous liver tumors and administered with PBS or pIC as indicated (arrows). n = 8 each group. C. Decreased mass ratio of liver tumor to non-tumorous liver tissue as harvested at week-4(†) from pIC- versus PBS-treated mice: 0.065 ± 0.069 vs.1.142 ± 1.161; p = 0.0006. D. Representative MRI scanning images of livers (left) and tumor volumes measured from these images (Right) showing slowed tumor growth and reduced tumor volume (mm3) in mice treated with pIC versus PBS: 3.7 ± 3.5 vs.87.1 ± 51.6; p < 0.0001. For all graphs, mean and SD are shown. *p < 0.05, ***p < 0.001, ****p < 0.0001, A&D. two-way ANOVA with Sidak's multiple comparisons test. B&C. Mann-Whitney Test.