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. 2015 Jul 11;6(29):27388–27402. doi: 10.18632/oncotarget.4489

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Copyright: © 2015 Lavik et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Left: Bcl-2 binds IP₃Rs and prevents Ca²⁺ elevation capable of inducing apoptosis. BIRD-2 inhibits Bcl-2-IP₃R interaction, thereby inducing apoptosis. Right: Bcl-2 binds BH3-only proteins and prevents them from inducing apoptosis. BH3 mimetic agents, such as ABT-263 and ABT-199, release BH3-only proteins from Bcl-2, thereby inducing apoptosis.