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. 2015 Aug 21;6(29):27427–27439. doi: 10.18632/oncotarget.4861

Figure 5. The positive feedback loop between Snail and DAB2IP exists in CRC cells.

Figure 5

A. Expressions of DAB2IP, p-GSK-3β, GSK-3β, Snail and β-catenin in Snail KD SW480 cells and Snail/DAB2IP KD SW480 cells with LiCL, MG132 treatments by Western blotting. B. TOP/FOP luciferase activity in Snail KD SW480 cells and Snail/DAB2IP KD SW480 cells with LiCL, MG132 treatments. C. Luciferase activity of DAB2IP promoter in Snail KD SW480 cells and Snail/DAB2IP KD SW480 cells with LiCL, MG132 treatments. D. Effects of Snail and Snail/DAB2IP KD on the proliferation of SW480 and HCT116 cells by MTT assay. E. Effect of Snail and Snail/DAB2IP KD on the invasiveness of SW480 and HCT116 cells by Boyden chamber. Scale bars represent 50 μm. F. Effect of Snail and Snail/DAB2IP KD on the migration of SW480 and HCT116 cells by Transwell chamber.