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. 2015 Jun 25;6(29):27478–27489. doi: 10.18632/oncotarget.4393

Figure 1. A2B receptor promotes tumor growth by altering the number of tumor-infiltrated immune cells.

Figure 1

A. Percentage of MDSC [CD11b positive (+) Gr1+] cells analyzed by FACS in tumor tissue of C57Bl6j mice bearing melanoma isografts and treated with Bay60-6583 0.2mg/kg or vehicle (ctr) from day 7 after tumor cells injection. B. Tumor growth was monitored during the treatment; at the end of the treatment (14 days after tumor cell implantation), mice were sacrificed to collect tumors. C, D and E. Percentage of CD3+CD8+ T cells, CD3 negative (−) NK1.1+ cells and CD3+NK1.1+ cells, respectively, analyzed by FACS in the tumor tissues of control and Bay60-6583-treated mice. Data are from two independent experiments and represent mean ± SEM (n = 6–9 per group). *p < 0.05.