Table 4. Multivariate analysis for disease recurrence in patients with T1a disease.

(A) In patients with pT1a disease
Variables		Hazard Ratio	95% CI	P
Nuclear ERα	positive vs. negative	2.27	1.08–4.77	0.03
Sex	males vs. females	2.19	1.06–4.53	0.035
Surgery	lobectomy vs. limited resection	3.55	1.69–7.49	<0.001
Architectural grade	high vs. intermediate	2.88	1.26–6.58	0.012
	high vs. low	11.67	1.60–84.75	0.015
Lymphatic Invasion	present vs. absent	1.18	0.56–2.51	0.67
Mitotic count	intermediate vs. low	0.67	0.23–1.95	0.46
	high vs. low	1.31	0.54–3.17	0.55

(B) Effect of nuclear ER in males and females with pT1a disease
Variables		Hazard Ratio	95% CI	P
Nuclear ERα in females	positive vs. negative	1.31	0.43–4.01	0.63
Nuclear ERα in males	positive vs. negative	3.66	1.37–9.74	0.009
Surgery	lobectomy vs. limited resection	3.49	1.65–7.36	0.001
Architectural grade	high vs. intermediate	2.99	1.25–7.15	0.014
	high vs. low	12.55	1.80–86.96	0.011
Lymphatic Invasion	present vs. absent	1.12	0.53–2.4	0.77
Mitotic count	intermediate vs. low	0.69	0.23–2.02	0.49
	high vs. low	1.33	0.53–3.33	0.54

Significant P-values (<0.05) are shown in bold.

ER, estrogen receptor; CI, confidence interval