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. 2015 Jul 20;6(29):28011–28025. doi: 10.18632/oncotarget.4377

Figure 3. Effect of TUDCA on the hepatic UPR pattern in the DEN-induced mouse model of HCC.

Figure 3

A. Real-time PCR analysis of the UPR targets Grp78 and Chop. B. Expression of Grp78, eIf2α, phospho-eIf2α, Chop, procaspase-12 and cleaved caspase-12 was detected using Western blotting. Results are representative of 2 independent experiments. C. Cleaved caspase-12/procaspase-12 ratio obtained using densitometric analysis of the Western blot shown in B. D. Effect of TUDCA treatment on the MTT metabolic activity of HepG2 cells (treated with tunicamycin (Tunica) or not). *p < 0.05, **p < 0.01, ***p < 0.001. Results are representative of 3 independent experiments.