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. 2015 Jul 20;6(29):28011–28025. doi: 10.18632/oncotarget.4377

Figure 6. Effect of TUDCA on the orthotopic and xenograft mouse models of HCC progression.

Figure 6

A. Representative images of murine livers treated for 25 weeks with DEN injections followed by 5 weeks of TUDCA-supplemented or control drinking water. B. Reticulin staining of the DEN-treated livers for C. quantification of tumor burden. Scale bar: 100 μm. D. Real-time PCR analysis of the UPR targets Grp78 and Chop. E. Expression of Grp78, eIf2α, phospho-eIf2α, Chop, procaspase-12 and cleaved caspase-12 was detected using Western blotting. Results are representative of 2 independent experiments. F. Effect of indicated treatments on growth of HepG2 xenografts in athymic nude mice (n = 6). The volume of each tumor was measured for 33 days. Values represent the mean ± SD. G. At the end of the treatment period, animals were sacrificed and tumor weights were recorded. *p < 0.05, **p < 0.01.