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. 2015 Jul 31;6(29):28327–28340. doi: 10.18632/oncotarget.5069

Figure 1. PDX faithfully replicate the morphology of the EOC of origin.

Figure 1

Most representative examples are shown here. O-3312 is a Grade 3 (Silverberg classification) Serous Carcinoma characterized by papillae proliferation and extended necrotic areas; O-2878 is a Grade 2 Serous Carcinoma with papillae architecture and psammoma; O-3006 is an undifferentiated Grade 3 Serous Carcinoma with solid architecture and large necrotic areas; O-1912 is a Clear Cell Carcinoma; O-1217 Grade 2 is a Carcino-Sarcoma (Mixed Mixed Müuuml;llerian tumors) showing inclusions of sarcomatous tissue within an undifferentiated epithelial carcinoma; O-2781 is a mucinous carcinoma with mucus material accumulating inside and outside tumor cells. Note that the characteristics observed in the original tumors were strikingly reproduced in the PDXs that were generated.