Figure 5. mutational profiles of O-2878, distant nodules O-0005D and O-0005S and the PDX that were derived from them.

A. mutations detected were indicated in shades of red ranging from dark red (100% of the calls) to light red (10% of the calls). White boxes indicate samples in which the mutation was not detected. B. Phylogenetic tree of the 3 tumor samples and their PDX offsprings. The 3 patient samples show greater proximity to each other than they do to their corresponding PDXs.