Table 1. Univariate and multivariate analyses of prognostic factors for overall and disease-free survival using Cox proportional hazards regression model (N =111).
| Variable | Disease-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Age(y) | ||||||||
| ≥ 46 | 1 | 1 | 1 | 1 | ||||
| < 46 | 0.846 | 0.504∼1.422 | 0.784 | 0.570∼1.442 | 0.864 | 0.489∼1.525 | 0.583 | 0.534∼1.929 |
| Gender | ||||||||
| Male | 1 | 1 | 1 | 1 | ||||
| Female | 0.819 | 0.410∼1.632 | 0.436 | 0.320∼1.661 | 0.980 | 0.471∼2.041 | 0.651 | 0.457∼1.653 |
| Primary tumor (T)stage | ||||||||
| T1∼2 | 1 | 1 | 1 | 1 | ||||
| T3∼4 | 0.709 | 0.411∼1.223 | 0.841 | 0.542∼1.347 | 0.842 | 0.463∼1.531 | 0.716 | 0.638∼1.742 |
| Lymph node (N) metastasis | ||||||||
| N0 | 1 | 1 | 1 | 1 | ||||
| N1∼3 | 1.933 | 0.842∼4.440 | 1.552 | 0.803∼3.213 | 1.740 | 0.756∼4.006 | 2.130 | 0.874∼2.683 |
| Clinical TNM staging | ||||||||
| I ∼ II | 1 | 1 | 1 | 1 | ||||
| III ∼ IVa | 6.394$ | 2.169∼18.850 | 6.328$ | 1.261∼17.528 | 6.191# | 1.798∼21.319 | 6.584# | 2.044∼21.214 |
| MiR-23a expression level | ||||||||
| Low | 1 | 1 | 1 | 1 | ||||
| High | 0.384$ | 0.222∼0.666 | 0.435# | 0.255∼0.743 | 0.357$ | 0.191∼0.667 | 0.392# | 0.214∼0.719 |
*P < 0.05, #P < 0.01, $P < 0.001. HR, hazard ratio; CI, confidence interval.