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. 2015 Jul 22;6(29):28371–28388. doi: 10.18632/oncotarget.4948

Figure 2. Comparison of VTRNA2-1-5p expression in cervical cancer tissue with inactivated p53 and in breast cancer tissue with mutated p53.

Figure 2

A. 3′-DIG-labeled VTRNA2-1-5p LNA probe, snRNA U6 (positive control probe), miR-159 (negative control probe), and p53 antibodies were used. All the ISH images (×200) show intermediate to high staining intensity for VTRNA2-1-5p. Cervical cancer tissue showed more intense staining than adjacent normal tissue. Immunostaining for p53 was essentially negative in cervical tissue and normal breast tissue but strong in breast cancer tissue (×200). All the images were taken with an Aperio ImageScope system. B. Statistical graph showing VTRNA2-1-5p expression, human snRNA U6 expression and miR-159 expression in cervical and breast tissue. n = 31; nonparametric tests.