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. 2015 Jul 22;6(29):28401–28424. doi: 10.18632/oncotarget.4951

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Copyright: © 2015 Fang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Seventy-nine early-stage oral cancer patients were divided into 4 groups based on the IHC staining of S100A9 and CD68 in tumor stroma. The pie chart shows the percentage of each group. B. Kaplan-Meier analysis showing the relation of recurrence-free survival with the expression of S100A9 and CD68 in stroma. High stromal S100A9 and high CD68 patients had the poorest clinical outcome compared with those with either one high or both low expression. C. High or Low expression of both CD68 staining and CD34+ microvessel density in the stroma of two clinical specimens by IHC staining. S, stroma; T, tumor. D. Pearson correlation analysis showing a positive correlation of CD34-positive microvessel number with stromal CD68 expression in tumor stroma.

A. Seventy-nine early-stage oral cancer patients were divided into 4 groups based on the IHC staining of S100A9 and CD68 in tumor stroma. The pie chart shows the percentage of each group. B. Kaplan-Meier analysis showing the relation of recurrence-free survival with the expression of S100A9 and CD68 in stroma. High stromal S100A9 and high CD68 patients had the poorest clinical outcome compared with those with either one high or both low expression. C. High or Low expression of both CD68 staining and CD34+ microvessel density in the stroma of two clinical specimens by IHC staining. S, stroma; T, tumor. D. Pearson correlation analysis showing a positive correlation of CD34-positive microvessel number with stromal CD68 expression in tumor stroma.