Figure 4. Transcriptional activation of Bim.

Bim transcription can be upregulated by a whole range of transcription factors (outlined in green) whose activities are tightly regulated. Some of these pathways are cell-type specific and depend on the stimulus. Those proteins positively regulating the transcription factors are presented in red, while those inhibiting in blue. H2AX is a histone whose phosphorylation at Ser139 by p38 is important for Bim transcription. The different pathways are described in more detail in Section 3.1.1.