Table 6. Bim in the Cancer Context.

Apoptotic Stimulus	Remarks	References
Granzyme B	• Bim-deficient 3T9 transformed mouse embryonic fibroblasts are resistant to Granzyme B-induced apoptosis.	[650]
IFNα	• IFNα-induced apoptosis of multiple myeloma cells depends on Jak1 and Bim.	[601]
Melatonin • (N-acetyl-5-methoxy-tryptamine)	• Melatonin induces apoptosis of HepG2 hepatoma cells through FoxO3a-mediated induction of Bim. • Melatonin induces apoptosis of human renal Caki cells by upregulating Bim through induction of SP-1 and E2F1-mediated transcription and inhibition of proteasomal activity.	[318, 320]
c-Myc induced apoptosis	• Bim mediates c-Myc induced apoptosis in solid tumors.	[191]
TGFβ-induced apoptosis	• Bim is the most downstream apoptotic effector of the TGFβ pathway, and its downmodulation abrogates TGFβ-dependent apoptosis in the gastric epithelial cell line SNU16. • TGFβ-induced apoptosis of adenomatous polyposis coli cells is mediated by Bim. • TGFβ1 induces human osteoclast apoptosis by upregulating Bim. • TGFβ induces Bim expression through a mechanism that involves Smad3/4, Runx1/3, p38 and JNK. • Runx1 cooperates with FoxO3a to transcriptionally induce Bim.	[42, 152, 153, 165, 166, 553-555]