Table 1. Characteristics of patients with acute-on-chronic hepatitis B liver failure included in this study, stratified by different outcomes.
| Variable | Survival group (n = 169) | Death group (n = 109) | P-value |
|---|---|---|---|
| Clinical parameters | |||
| Age (years) | 42.04 ± 12.29 | 51.63 ± 12.4 | <0.001 |
| Male gender No.(%)* | 133 (78.7%) | 82 (75.2%) | 0.500 |
| Hepatic encephalopathy No.(%)* | 12 (7.1%) | 45 (41.3%) | <0.001 |
| Liver cirrhosis No.(%)* | 54 (32.0%) | 73 (67.0%) | <0.001 |
| Infection No.(%)* | 45 (26.6%) | 56 (51.4%) | <0.001 |
| Ascites No.(%)* | 80 (47.3%) | 76 (79.7%) | <0.001 |
| Hepatorenal syndrome No.(%)* | 7 (4.1%) | 8 (7.3%) | 0.249 |
| Laboratory parameters | |||
| White blood cell (1012/L) | 7.35 ± 5.01 | 7.41 ± 4.05 | 0.910 |
| Haemoglobin (g/L) | 127.31 ± 21.96 | 121.62 ± 23.07 | 0.042 |
| Platelet (109/L) | 45.27 ± 31.07 | 47.39 ± 28.99 | 0.569 |
| Serum sodium (mmol/L) | 137.18 ± 4.89 | 134.72 ± 5.67 | <0.001 |
| ALT (U/L) | 624.21 ± 659.74 | 540.76 ± 628.16 | 0.295 |
| AST (U/L) | 483.76 ± 536.35 | 566.26 ± 834.14 | 0.316 |
| Albumin (g/L) | 31.43 ± 5.89 | 29.94 ± 5.43 | 0.032 |
| Alkaline phosphatase (U/L) | 144.6 ± 47.03 | 166.68 ± 71.62 | 0.002 |
| Total bilirubin (μmol/L) | 270.38 ± 153.14 | 330.89 ± 170.34 | 0.002 |
| Creatinine (μmol/L) | 67.25 ± 26.46 | 84.95 ± 56.55 | <0.001 |
| INR | 2.49 ± 1.64 | 2.9 ± 1.22 | 0.025 |
| Scoring systems | |||
| MELD score | 23.3 ± 6.39 | 28.9 ± 8.98 | <0.001 |
| Child score | 8.73 ± 1.58 | 9.71 ± 1.4 | <0.001 |
NOTE: ALT, alanine aminotranferase; AST, aspartate aminotranferase; INR, international normalized ratio; MELD, model for end-stage liver disease.
*
Dichotomous values.