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. 2015 Jun 23;6(27):23342–23357. doi: 10.18632/oncotarget.4344

Figure 1. Relative expression of the lncRNA AOC4P in HCCs and its clinical significance.

Figure 1

A. The expression of AOC4P was examined in 108 paired human HCC and noncancerous normal tissues via qRT-PCR. GAPDH expression was assessed as an internal control. The results were presented as the fold-change in AOC4P expression tumor tissues relative to that in normal tissues. The expression of AOC4P was significantly lower in tumor tissues than in normal tissues (p < 0.001). B. In situ hybridization for AOC4P in HCC and in noncancerous normal tissues. AOC4P expression was notably reduced in HCC samples. C and D. AOC4P expression was significantly lower in patients with more advanced pathological stage tumors and with larger tumor size. E and F. Kaplan-Meier curve presenting the disease-free survival and the overall survival of HCC patients exhibiting high or low AOC4P expression. Lower AOC4P expression levels (relative expression level < 0.25) in the tumor tissues were associated with a poor prognostic outcome.