Table 2. Summary of copy number changes observed in analyzed miRNA and miRNA biogenesis genes in NSCLC samples.
| expression | copy number: median (average) | gains: number (%) | amplifications: number (%) | losses:number (%) | hom. deletions: number (%) | informative samples # | |
|---|---|---|---|---|---|---|---|
| miR-126 | ↓ | 1.73 (1.76) | 1 (0.4) | 0 (0) | 26 (10.8) | 3 (1.2) | 241 |
| miR-200b | ↑ | 1.76 (1.84) | 2 (0.9) | 1 (0.4) | 18 (7.7) | 0 (0) | 235 |
| miR-182 | ↑ | 1.78 (1.81) | 1 (0.4) | 0 (0) | 9 (3.8) | 0 (0) | 240 |
| miR-451a | ↓ | 1.84 (1.89) | 6 (2.5) | 0 (0) | 12 (5.0) | 4 (1.7) | 239 |
| miR-210 | ↑ | 1.85 (1.87) | 1 (0.4) | 0 (0) | 9 (4.0) | 0 (0) | 227 |
| miR-31 | ↑ | 1.99 (2.11) | 22 (10.0) | 6 (2.7) | 20 (9.1) | 8 (3.7) | 219 |
| miR-486 | ↓ | 2.06 (2.11) | 7 (3.0) | 2 (0.9) | 3 (1.3) | 2 (0.9) | 233 |
| miR-143 | ↓ | 2.14 (2.16) | 12 (5.9) | 2 (1.0) | 8 (3.9) | 3 (1.5) | 205 |
| miR-155 | ↑ | 2.33 (2.50) | 33 (13.5) | 23 (9.4) | 21 (8.6) | 5 (2.0) | 245 |
| miR-17 | ↑ | 2.42 (2.62) | 39 (16.0) | 28 (11.5) | 15 (6.1) | 5 (2.0) | 244 |
| miR-205 | ↑ | 2.59 (2.61) | 45 (19.0) | 8 (3.4) | 1 (0.4) | 0 (0) | 237 |
| DICER1 | ↓/↑ | 2.60 (2.69) | 51 (21.8) | 23 (9.8) | 8 (3.4) | 3 (1.3) | 234 |
| miR-21 | ↑ | 2.63 (2.90) | 48 (22.7) | 25 (11.8) | 6 (2.8) | 0 (0) | 211 |
| miR-30a | ↓ | 2.67 (2.90) | 59 (23.8) | 40 (16.1) | 14 (5.6) | 6 (2.4) | 248 |
| miR-30d | ↓ | 2.77 (3.02) | 63 (26.6) | 35 (14.8) | 3 (1.3) | 1 (0.4) | 237 |
| DROSHA | ↑ | 2.79 (3.00) | 67 (30.7) | 23 (10.6) | 0 (0) | 0 (0) | 218 |
| MET | ↑ | 2.45 (2.50) | 23 (9.9) | 5 (2.2) | 1 (0.4) | 0 (0) | 232 |
| EGFR | ↑ | 2.41 (2.55) | 13 (5.3) | 5 (2.0) | 1 (0.4) | 1 (0.4) | 246 |