Table 1. NCI-Nature Curated pathways obtained by Pathway Interaction Database analysis of up-regulated genes.
| Pathway Name | Biomolecules in Group | P Value |
|---|---|---|
| a6b1 and a6b4 Integrin signaling | LAMBS, SFN | 1.68E-03* |
| PDGFR-beta signaling pathway | SFN, SPHK1 | 1.25E-02* |
| Alpha6 beta4 integrin-ligand interactions | LAMBS | 1.53E-02* |
| S1P1 pathway | SPHK1 | 2.89E-02* |
| p38 signaling mediated by MAPKAP kinases | SFN | 2.89E-02* |
| Sphingosine-l-phosphate (S1P) pathway | SPHK1 | 2.89E-02* |
| Signaling events mediated by PRL | PTP4A3 | 3.15E-02* |
| Alpha9 beta1 integrin signaling events | ADAMS8 | 3.42E-02* |
| Insulin-mediated glucose transport | SFN | 3.95E-02* |
| Class I PI3K signaling events mediated by Akt | SFN | 4.86E-02* |
| Trk receptor signaling mediated by PI3K and PLC-gamma | SFN | 4.99E-02* |
| Signaling mediated by p38-alpha and p38-beta | KRT19 | 5.12E-02 |
| Beta3 integrin cell surface interactions | SPHK1 | 5.88E-02 |
| Validated transcriptional targets of deltaNp63 isoforms | SFN | 6.38E-02 |
| LKB1 signaling events | SFN | 6.38E-02 |
| FoxO family signaling | SFN | 6.63E-02 |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | SFN | 7.62E-02 |
| Fc-epsilon receptor I signaling in mast cells | SPHK1 | 7.98E-02 |
| HIF-1-alpha transcription factor network | PKM | 8.71E-02 |
| Beta1 integrin cell surface interactions | LAMBS | 9.06E-02 |
| mTOR signaling pathway | SFN | 9.06E-02 |
| p73 transcription factor network | SFN | 1.01E-01 |
| Regulation of nuclear beta catenin signaling and target gene transcription | SFN | 1.03E-01 |
| Glucocorticoid receptor regulatory network | SFN | 1.06E-01 |
| ErbB1 downstream signaling | SFN | 1.36E-01 |
| Direct p53 effectors | SFN | 1.66E-01 |
*
P < 0.05