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. 2015 Jun 29;6(27):24092–24104. doi: 10.18632/oncotarget.4483

Figure 5. YXM110 inhibits HIF-1α translation.

Figure 5

A. HIF-1α mRNA was analyzed with quantitative real-time RT-PCR after 6 h treatment of YXM110 (0.1 or 0.3 μM) under normoxia or hypoxia conditions. B. HCT116 cells were treated with vehicle (0.1% DMSO) or YXM110 (0.1 or 0.3 μM) under normoxia or hypoxia conditions for 24 h or C. pretreated with vehicle or 10 μM MG132 and then incubated with vehicle or YXM110 (0.1 or 0.3 μM) for 24 h under hypoxia. The cells were then harvested for detection of HIF-1α and actin by western blot analysis. *P < 0.05; ## P < 0.01.