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. 2015 Jun 29;6(27):24092–24104. doi: 10.18632/oncotarget.4483

Figure 6. YXM110 inhibits HRE-Luciferases activity and VEGF transcription and translation.

Figure 6

A. HCT116 cells transiently transfected with 5-HRE-Luciferase reporter were treated with YXM110 under normoxia or hypoxia conditions for 24 h. Data have shown represented luciferase activity relative to the control. B. VEGFA mRNA was analyzed with quantitative real-time RT-PCR after 6 h treatment of YXM110 (0.1 or 0.3 μM) under normoxia or hypoxia conditions. C. VEGF levels in culture medium were determined using Human VEGF Quantikine ELISA Kit. ***P < 0.001; ###P < 0.001.