Figure 6. Enrichment plots and heat maps of selected gene sets detected by GSEA in U266 treated with vemurafenib in comparison with DMSO controls.

A., C. The green curves show the enrichment score and reflect the degree to which each gene (black vertical lines) is represented at the bottom of the ranked gene list. Normalized enrichment score (NES) and FDRs are shown for each gene set; the gene sets with an FDR of <0.05 were considered enriched. B., D. Heat maps of the genes constituting the leading edge subsets within the gene sets shown in panels A and C, respectively, in treated and control U266 cells.