Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 8;6(27):24404–24423. doi: 10.18632/oncotarget.4380

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2015 Pedrosa et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

A. Representative images of Hif1α immunofluorescence (green) (20x amplification) (maximum intensity projections) in TRAMP endothelial-specific Jag1 mutants (OE and KO). B. Quantification of Hif1α positive area per field (pixel²) demonstrating increased stained areas in TRAMP.eJag1OE and decreased staining in TRAMP.eJag1cKO relative to respective controls. C. Hypoxypyprobe immunohistochemical staining, in early (18 wks) and late (24 wks) stages of tumor progression, showing strong positive staining in TRAMP.eJag1OE while TRAMP.eJag1cKO mutants present weak positive signal, compared with controls (TRAMP Ctrl). D. Relative fold Hif1α mRNA expression showing increased expression in TRAMP.eJag1OE and decreased expression in TRAMP.eJag1cKO mutants, at 18 weeks of age. DAPI (blue) stains nuclei. Error bars represent SEM; * represents p < 0.05; ** represents p < 0.01; *** represents p < 0.001.