Skip to main content
. 2015 Jun 8;6(27):24404–24423. doi: 10.18632/oncotarget.4380

Figure 7. rostate cellular apoptosis and proliferation in TRAMP endothelial-specific Jag1 mutants.

Figure 7

A. Representative images of active Caspase3 (green) and Ki67 (red) immunofluorescence staining (20x amplification) (maximum intensity projections) in TRAMP endothelial-specific Jag1 mutants (OE and KO). B. Prostatic lesions of TRAMP.eJag1OE mutants presented decreased percentage of active caspase3 positive area per field, relative to control (100%), either at 18 as at 24 weeks of age. C. Prostate samples from TRAMP.eJag1OE presented increased percentage of Ki67 positive area per field, relative to control (100%), at both time points (18 and 24 wks) D. Prostatic lesions of TRAMP.eJag1cKO mutants presented increased percentage of active caspase3 positive area per field, relative to control (100%), at 18 and 24 weeks of age. E. Prostate samples from TRAMP.eJag1cKO presented decreased percentage of Ki67 positive area per field, relative to control (100%), at both time points (18 and 24 wks). F. Relative fold mRNA expression of cell cycle regulatory genes in TRAMP.eJag1OE and TRAMP.eJag1cKO mutants, at 24 weeks of age. DAPI (blue) stains nuclei. Error bars represent SEM; * represents p < 0.05; ** represents p < 0.01; *** represents p < 0.001.