Table 2. Relationship between miR-99b-5p expression and clinicopathologic parameters in chemotherapy-naïve patients with synchronous colorectal cancer liver metastases (n = 23).
| Characteristic | No. | Percent | miR-99b-5p in primary tumor(mean±SEM) | P value | miR-99b-5p in liver metastases(mean±SEM) | P value |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 13 | 56.5 | 11.8715±8.14648 | 0.455 | 1.7069±0.49799 | 0.364 |
| Female | 10 | 43.5 | 4.5740±2.45382 | 1.0710±0.43560 | ||
| Age (years) | ||||||
| Median (range) | 52 (28-72) | |||||
| <60 | 16 | 69.6 | 9.0431±6.68341 | 0.915 | 1.3413±0.41877 | 0.700 |
| ≥60 | 7 | 30.4 | 7.9114±3.34287 | 1.6343±0.60836 | ||
| Primary tumor site | ||||||
| Colon | 5 | 21.7 | 27.89±20.68175 | 0.302 | 1.8260±0.85487 | 0.551 |
| Rectum | 18 | 78.3 | 3.3678±0.97034 | 1.3206±0.37239 | ||
| pT | ||||||
| 2+3 | 5 | 21.7 | 4.644±2.76588 | 0.660 | 2.2700±0.97958 | 0.198 |
| 4 | 18 | 78.3 | 9.8250±5.97868 | 1.1972±0.33507 | ||
| pN | ||||||
| Negative | 4 | 17.4 | 1.8875±0.64400 | 0.519 | 1.0925±0.73401 | 0.658 |
| Positive | 19 | 82.6 | 10.1326±5.66261 | 1.5016±0.38629 | ||
| Perineural invasion | ||||||
| Positive | 8 | 34.8 | 2.1937±1.25798 | 0.24 | 0.56±0.37358 | 0.037* |
| Negative | 11 | 47.8 | 15.9673±9.52915 | 1.9091±0.43051 | ||
| NK | 4 | 17.4 | ||||
| Vascular invasion | ||||||
| Positive | 5 | 21.7 | 3.1360±1.94324 | 0.474 | 0.7680±0.59202 | 0.309 |
| Negative | 14 | 60.9 | 12.6793±7.61171 | 1.5457±0.38797 | ||
| NK | 4 | 17.4 | ||||
| Differentiation | ||||||
| Poor/moderate-poor | 7 | 30.4 | 3.6797±1.59738 | 0.493 | 1.1413±0.46560 | 0.583 |
| Moderate/high-moderate | 16 | 69.6 | 10.8951±6.71938 | 1.5578±0.44751 | ||
| Combined with other metastases | ||||||
| Yes | 4 | 17.4 | 4.4200±2.15275 | 0.686 | 1.1900±0.66402 | 0.753 |
| No | 19 | 82.6 | 9.5995±5.68460 | 1.4811±0.39173 | ||
Abbreviations: NK, not known; pN, pathologic node; pT, pathologic tumor; SEM, standard error of the mean.
*
Denotes significance.